Tag Archives: Alzheimer’s Disease

New Hope In Treatment For Dementia And Alzheimer’s Disease

This is encouraging news.

If you have a parent who’s suffering from Alzheimer’s disease and you’re worried about the future, there may be really good news for you and your parents: scientists in Great Britain may have found a solution to stop all neurodegenerative brain diseases, including dementia.

Prior to the most recent discovery, the best scientists could do was terminate brain cells dying in an animal in 2013. Unfortunately the drug used caused organ damage.

But now, two drugs used at the MRC Toxicology Unit in Leicester have been safely used in people. Prof Giovanna Mallucci, from that unit, is so excited she wants to start human clinical trials on dementia patients. DailyWire

Two drugs that show potential are already being used on humans

Two were shown to prevent both a form of dementia and prion disease by stopping brain cells dying.

Prof Mallucci told the BBC News website: “Both were very highly protective and prevented memory deficits, paralysis and dysfunction of brain cells.”

The best known drug of the pair is trazodone, which is already taken by patients with depression.

The other, DBM, is being tested in cancer patients.  BBC.

Drugs have potential to work on several conditions

Dr Doug Brown, director of research and development at Alzheimer’s Society said: “We’re excited by the potential of these findings.

“They show that a treatment approach originally discovered while researching prion disease might also work to prevent the death of brain cells in some forms of dementia.

“This research is at a very early stage and has not yet been tested in people – but as one of the drugs is already available as a treatment for depression, the time taken to get from the lab to the pharmacy could be dramatically reduced.”

“The drug blocks a natural defence mechanism in cells which is overactive in the brains of people with frontotemporal dementia, Alzheimer’s disease and Parkinson’s, so has the potential to work for several conditions.

“So far it has only been tested in mice with frontotemporal dementia but Alzheimer’s Society is now funding the researchers to test it in models of Alzheimer’s too.” Leicester Mercury